Casx.cat - CasX enzymes comprise a distinct family of RNA-guided genome …

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WEBFeb 4, 2019 · Nature - CRISPR–CasX represents a distinct RNA-guided platform that is functionally separate from Cas9 and Cas12a and is active for bacterial and human genome modification.

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CasX enzymes comprise a distinct family of RNA-guided genome …
nature.com

https://www.nature.com/articles/s41586-019-0908-x

WEBFeb 4, 2019 · Nature - CRISPR–CasX represents a distinct RNA-guided platform that is functionally separate from Cas9 and Cas12a and is active for bacterial and human genome modification.

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CasX: a new and small CRISPR gene-editing protein | Cell …
nature.com

https://www.nature.com/articles/s41422-019-0165-4

WEBApr 16, 2019 · CasX was identified by metagenomic analysis of bacteria from groundwater and characterized as an RNA-guided DNA nuclease. 7 It recognizes a 5′-TTCN PAM and is capable of plasmid interference in...

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CasX start-up Scribe Therapeutics raises $100 million for …
acs.org

https://cen.acs.org/pharmaceuticals/gene-therapy/CasX-startScribe-Therapeutics-raises-100/99/i12

WEBMar 31, 2021 · CasX start-up Scribe Therapeutics raises $100 million for CRISPR therapies. Gene Therapy. CasX start-up Scribe Therapeutics raises $100 million for CRISPR therapies. The start-up is applying protein engineering to create new CasX enzymes for neurodegenerative diseases and more. by Ryan Cross.

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CRISPR-CasX is an RNA-dominated enzyme active for human …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662743/

WEBHere we present a third and fundamentally distinct RNA-guided platform, CRISPR-CasX, which uses a unique structure and mechanism for programmable double-stranded DNA cleavage. Biochemical and in vivo data demonstrate that CasX is active for E. coli and human genome modification.

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Chimeric CRISPR-CasX enzymes and guide RNAs for improved …
nih.gov

https://pubmed.ncbi.nlm.nih.gov/35219382/

WEBMar 17, 2022 · A compact protein with a size of <1,000 amino acids, the CRISPR-associated protein CasX is a fundamentally distinct RNA-guided nuclease when compared to Cas9 and Cas12a. Although it can induce RNA-guided genome editing in mammalian cells, the activity of CasX is less robust than that of the widel …

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New CRISPR–Cas systems from uncultivated microbes | Nature
nature.com

https://www.nature.com/articles/nature21059

WEBDec 22, 2016 · Among the 155 million protein-coding genes analysed, we identified the first Cas9 proteins in domain Archaea, and discovered two new CRISPR–Cas systems in uncultivated bacteria, which we refer...

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CasX: a new and small CRISPR gene-editing protein - PMC
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796933/

WEBApr 16, 2019 · Taken together, the contribution by Liu et al. 8 has uncovered mechanisms of new Cas member CasX for DNA unwinding, cleavage of both DNA strands, and domain movements during transition between two states. Their findings raise the prospect for development of CasX-based gene editing tools.

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Chimeric CRISPR-CasX enzymes and guide RNAs for improved …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189900/

WEBMar 3, 2022 · A compact protein with a size of < 1,000 amino acids, the CRISPR-associated protein CasX is a fundamentally distinct RNA-guided nuclease compared to Cas9 and Cas12a. Although it can induce RNA-guided genome editing in mammalian cells, the activity of CasX is less robust than that of the widely used S. pyogenes Cas9.

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Scientists find new and smaller CRISPR gene editor: CasX
berkeley.edu

https://chemistry.berkeley.edu/news/scientists-find-new-and-smaller-crispr-gene-editor-casx

WEBFeb 5, 2019 · By Robert Sanders | UC Berkeley media relations. A new gene-editing protein, CasX, may give CRISPR-Cas9 a run for its money. UC Berkeley scientists have determined the unique structure of CasX (grey), revealing that this pint-sized Cas enzyme is dominated by RNA (red) that directs it to specific sequences of DNA (blue), where it …

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The Little Enzyme That Can: Meet the Gene Editor CasX
innovativegenomics.org

https://innovativegenomics.org/news/the-little-enzyme-that-can-meet-the-gene-editor-casx/

WEBFeb 4, 2019 · The Little Enzyme That Can: Meet the Gene Editor CasX. February 4, 2019 Press Releases. From mystery to discovery: CasX becomes “Cas!!!”. Scientists use the letter “X” to designate the mysterious (such as X-rays, and the X chromosome, when both were first discovered). Meet the newest entry, CasX, the mystery of which was cracked …

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Casx.cat - CasX enzymes comprise a distinct family of RNA-guided genome …

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