Keyword Analysis & Research: zrsr2 mutation


Keyword Analysis

Keyword CPC PCC Volume Score Length of keyword
zrsr2 mutation1.73114636014
zrsr20.60.16248215
mutation1.890.99743788

Keyword Research: People who searched zrsr2 mutation also searched

Keyword CPC PCC Volume Score
zrsr2 mutation1.220.6542823
zrsr2 mutation mds1.40.680283
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Search Results related to zrsr2 mutation on Search Engine

  • ZRSR2 - My Cancer Genome

    mycancergenome.org

    https://www.mycancergenome.org/content/gene/zrsr2/

    WEBThe most common alterations in ZRSR2 are ZRSR2 Mutation (0.65%), ZRSR2 Loss (0.39%), ZRSR2 Nonsense (0.10%), ZRSR2 Amplification (0.09%), and ZRSR2 X276_splice (0.03%) . ZRSR2 GENIE Cases - Top Alterations

    DA: 72 PA: 44 MOZ Rank: 98

  • ZRSR2 Mutation Induced Minor Intron Retention Drives MDS and …

    ashpublications.org

    https://ashpublications.org/blood/article/136/Supplement%201/10/470256/ZRSR2-Mutation-Induced-Minor-Intron-Retention

    WEBNov 5, 2020 · Mutations in the splicing factors SF3B1, SRSF2, and U2AF1 occur as heterozygous, missense mutations and have been shown to confer a change-of-function. In contrast, the X chromosome encoded ZRSR2 is enriched in nonsense/frameshift mutations in males, consistent with loss of function.

    DA: 75 PA: 44 MOZ Rank: 20

  • Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic

    nature.com

    https://www.nature.com/articles/s41375-022-01674-2

    WEBAug 27, 2022 · Importantly, mutations in the splicing factor ZRSR2 frequently associate with alterations in the epigenetic regulator TET2. However, the impact of these concurrent mutations in hematopoiesis...

    DA: 43 PA: 68 MOZ Rank: 44

  • Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair …

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831459/

    WEBFeb 2, 2022 · Loss-of-function mutations in ZRSR2, an X chromosome gene encoding a splicing factor, are enriched in BPDCN, and nearly all mutations occur in males. ZRSR2 mutation impairs pDC activation and apoptosis after inflammatory stimuli, associated with intron retention and inability to upregulate the transcription factor IRF7.

    DA: 55 PA: 34 MOZ Rank: 26

  • ZRSR2 Mutations Cause Dysregulated RNA Splicing in MDS

    ashpublications.org

    https://ashpublications.org/blood/article/124/21/4609/94026/ZRSR2-Mutations-Cause-Dysregulated-RNA-Splicing-in

    WEBDec 6, 2014 · Mutations in ZRSR2are more prevalent in MDS subtypes without ring sideroblasts and chronic myelomonocytic leukemia (CMML) and are associated with elevated bone marrow blasts and higher rate of progression to AML. Although ZRSR2 has been suggested to interact with other splice proteins, U2AF2 and SRSF2, at the 3΄ …

    DA: 88 PA: 80 MOZ Rank: 38

  • Minor intron retention drives clonal hematopoietic disorders and

    nature.com

    https://www.nature.com/articles/s41588-021-00828-9

    WEBApr 12, 2021 · For example, the minor spliceosome component ZRSR2 is subject to recurrent, leukemia-associated mutations, yet functional connections among minor introns, hematopoiesis and cancers are unclear.

    DA: 85 PA: 15 MOZ Rank: 40

  • RNA splicing dysregulation and the hallmarks of cancer

    nature.com

    https://www.nature.com/articles/s41568-022-00541-7

    WEBJan 10, 2023 · Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types. Cancer-associated splicing alterations arise from both recurrent mutations and altered expression of...

    DA: 72 PA: 54 MOZ Rank: 58

  • Spliceosomal Factor Mutations and Mis-splicing in MDS - PMC

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8078562/

    WEBSince ZRSR2 mutations are typically frameshift and occur throughout the gene, they are likely loss of function. Knockdown of ZRSR2 in the cell lines HEK293T, TF-1, and K562 resulted in decreased splicing efficiency of U12-dependent introns, although U2 introns were largely unaffected.

    DA: 18 PA: 33 MOZ Rank: 60

  • ZRSR2 Mutations Cause Dysregulated RNA Splicing in MDS

    sciencedirect.com

    https://www.sciencedirect.com/science/article/pii/S0006497119735149

    WEBDec 6, 2014 · ZRSR2 Mutations Cause Dysregulated RNA Splicing in MDS - ScienceDirect. Volume 124, Issue 21, 6 December 2014, Page 4609. 636. Myelodysplastic Syndromes – Basic and Translational Studies: Poster III. ZRSR2 Mutations Cause Dysregulated RNA Splicing in MDS. Vikas Madan PhD * 1. , Deepika Kanojia PhD * 1. , …

    DA: 81 PA: 17 MOZ Rank: 100

  • Concurrent Zrsr2 mutation and Tet2 loss promote myelodysplastic

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9522584/

    WEBAug 27, 2022 · Mutations in ZRSR2 are very diverse and comprise nonsense, frameshift, missense, and splice-site mutations. While different hotspots are affected in other mutated splicing factors, mutations in ZRSR2 distribute across the entire coding region leading to protein loss-of-function [ 3 ].

    DA: 78 PA: 2 MOZ Rank: 3